Reactome | Liganded-ALK dimer binds type I ALK-binding TKIs

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Liganded-ALK dimer binds type I ALK-binding TKIs Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722758
displayName	Liganded-ALK dimer binds type I ALK-binding TKIs
eventOf	[Pathway:R-XTR-201556] Signaling by ALK - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs - Homo sapiens
input	[CandidateSet:R-XTR-9850908] ligand-bound ALK dimer [plasma membrane] [DefinedSet:R-ALL-9699973] type I ALK-binding TKIs [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Liganded-ALK dimer binds type I ALK-binding TKIs
output	[Complex:R-XTR-9700592] ALK dimer:ligand:type I ALK binding TKI [plasma membrane]
precedingEvent	[Reaction:R-XTR-9842656] ALK binds ALKAL ligand - Xenopus tropicalis [Reaction:R-XTR-9667914] ALK binds ligand midkine (MDK) - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9700662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-201556] Signaling by ALK
(inferredTo)	[Reaction:R-HSA-9700662] Liganded-ALK dimer binds type I ALK-binding TKIs

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