Reactome | ROCK1,2 bind ROCKi

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722463
displayName	ROCK1,2 bind ROCKi
eventOf	[Pathway:R-XTR-5627117] RHO GTPases Activate ROCKs - Xenopus tropicalis [Pathway:R-XTR-416482] G alpha (12/13) signalling events - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9680443] ROCK1,2 bind ROCKi - Homo sapiens
input	[DefinedSet:R-XTR-419057] ROCK1,ROCK2 [cytosol] [DefinedSet:R-ALL-9686558] ROCKi [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ROCK1,2 bind ROCKi
output	[Complex:R-XTR-9680444] ROCK1,ROCK2:ROCKi [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9680443
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-416482] G alpha (12/13) signalling events [Pathway:R-XTR-5627117] RHO GTPases Activate ROCKs [Pathway:R-XTR-416572] Sema4D induced cell migration and growth-cone collapse
(inferredTo)	[Reaction:R-HSA-9680443] ROCK1,2 bind ROCKi