Reactome | JAK3 binds JAK3 inhibitors

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722443
displayName	JAK3 binds JAK3 inhibitors
eventOf	[Pathway:R-XTR-6785807] Interleukin-4 and Interleukin-13 signaling - Xenopus tropicalis [Pathway:R-XTR-9020558] Interleukin-2 signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9679028] JAK3 binds JAK3 inhibitors - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-451893] JAK3 [cytosol] [DefinedSet:R-ALL-9678772] JAK3 inhibitors [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	JAK3 binds JAK3 inhibitors
output	[Complex:R-XTR-9678869] JAK3:JAK3 inhibitors [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9679028
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-6785807] Interleukin-4 and Interleukin-13 signaling [Pathway:R-XTR-1266695] Interleukin-7 signaling [Pathway:R-XTR-9020558] Interleukin-2 signaling [Pathway:R-XTR-8985947] Interleukin-9 signaling
(inferredTo)	[Reaction:R-HSA-9679028] JAK3 binds JAK3 inhibitors