Reactome | factor XIa binds APP(18-770)

Schema > Reaction > Entries

factor XIa binds APP(18-770) Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722191
displayName	factor XIa binds APP(18-770)
eventOf	[Pathway:R-XTR-9769739] Regulation of clotting cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
inferredFrom	[Reaction:R-HSA-9657706] factor XIa binds APP(18-770) - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-49335] app [extracellular region] [Complex:R-XTR-158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XIa binds APP(18-770) factor XIa binds PN2
output	[Complex:R-XTR-9657716] factor XIa:APP (18-770) [extracellular region]
precedingEvent	[Reaction:R-XTR-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Xenopus tropicalis [Reaction:R-XTR-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Xenopus tropicalis [Reaction:R-XTR-481007] Exocytosis of platelet alpha granule contents - Xenopus tropicalis
regulatedBy	[PositiveRegulation:9653824] Positive regulation by 'Heparins [plasma membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9657706
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-9657706] factor XIa binds APP(18-770)