Reactome | factor XIa binds SERPINE1

Schema > Reaction > Entries

factor XIa binds SERPINE1 Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10722173
displayName	factor XIa binds SERPINE1
eventOf	[Pathway:R-XTR-9769739] Regulation of clotting cascade - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:1221431] negative regulation of blood coagulation, intrinsic pathway
inferredFrom	[Reaction:R-HSA-9655851] factor XIa binds SERPINE1 - Homo sapiens
input	[Complex:R-XTR-158130] factor XIa:GPIb:GPIX:GPV complex [plasma membrane] [EntityWithAccessionedSequence:R-XTR-158797] serpine1 [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	factor XIa binds SERPINE1 factor XIa binds PAI-1
output	[Complex:R-XTR-9655836] SERPINE1:factor XIa:GPIb:GPIX:GPV complex [plasma membrane]
precedingEvent	[Reaction:R-XTR-158300] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (XIIa catalyst) - Xenopus tropicalis [Reaction:R-XTR-158419] factor XI:platelet glycoprotein (GP) Ib:IX:V complex -> factor XIa:platelet glycoprotein (GP) Ib:IX:V complex (thrombin catalyst) - Xenopus tropicalis [Reaction:R-XTR-481007] Exocytosis of platelet alpha granule contents - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9655851
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9769739] Regulation of clotting cascade
(inferredTo)	[Reaction:R-HSA-9655851] factor XIa binds SERPINE1