Reactome | LARGE1,2 elongates matriglycan chain with GlcA

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LARGE1,2 elongates matriglycan chain with GlcA Show undefined attributes

catalystActivity	[CatalystActivity:10721755] glucuronosyltransferase activity of B4GAT1:LARGE [Golgi membrane]
category	transition
compartment	[Compartment:17963] Golgi lumen [Compartment:20699] Golgi membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10721757
displayName	LARGE1,2 elongates matriglycan chain with GlcA
eventOf	[Pathway:R-XTR-9939291] Matriglycan biosynthesis on DAG1 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-9940718] CHST10 sulfates matriglycan chain - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9638097] LARGE1,2 elongates matriglycan chain with GlcA - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-9940697] dag1 [Golgi lumen] [SimpleEntity:R-ALL-1889970] UDP-GlcA [Golgi lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	LARGE1,2 elongates matriglycan chain with GlcA B4GAT1:LARGE transfers GlcA from UDP-GlcA to Xyl-GlcA
output	[EntityWithAccessionedSequence:R-XTR-9940706] dag1 [Golgi lumen] [SimpleEntity:R-ALL-425969] H+ [Golgi lumen] [SimpleEntity:R-ALL-205687] UDP [Golgi lumen]
precedingEvent	[Reaction:R-XTR-9638090] LARGE1,2 elongates matriglycan chain with Xyl - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9638097
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9939291] Matriglycan biosynthesis on DAG1
(precedingEvent)	[Reaction:R-XTR-9940718] CHST10 sulfates matriglycan chain
(inferredTo)	[Reaction:R-HSA-9638097] LARGE1,2 elongates matriglycan chain with GlcA

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