Reactome | Activated NTRK2 binds FRS2

Schema > Reaction > Entries

category	binding
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10720612
displayName	Activated NTRK2 binds FRS2
eventOf	[Pathway:R-XTR-9028731] Activated NTRK2 signals through FRS2 and FRS3 - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9028730] Activated NTRK2 binds FRS2 - Homo sapiens
input	[DefinedSet:R-XTR-9026521] BDNF,NTF4:p-5Y-NTRK2 [plasma membrane] [EntityWithAccessionedSequence:R-XTR-190244] frs2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Activated NTRK2 binds FRS2
output	[Complex:R-XTR-9031934] BDNF,NTF4:p-5Y-NTRK2:FRS2 [plasma membrane]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9028730
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-9028731] Activated NTRK2 signals through FRS2 and FRS3
(inferredTo)	[Reaction:R-HSA-9028730] Activated NTRK2 binds FRS2

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