Reactome | Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)

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Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) Show undefined attributes

catalystActivity	[CatalystActivity:10689110] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen of Ac-PTGS2 dimer [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10720600
displayName	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)
eventOf	[Pathway:R-XTR-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-9027627] Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages) - Homo sapiens
input	[SimpleEntity:R-ALL-9024011] DHA [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)
output	[SimpleEntity:R-ALL-9027622] 17-HDHA [cytosol]
precedingEvent	[Reaction:R-XTR-2314686] ASA- acetylates PTGS2 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9027627
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-9027604] Biosynthesis of electrophilic ?-3 PUFA oxo-derivatives
(inferredTo)	[Reaction:R-HSA-9027627] Ac-PTGS2 dimer oxidises DHA to 17-HDHA (macrophages)

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