Reactome | C3PO hydrolyzes cleaved passenger strand

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C3PO hydrolyzes cleaved passenger strand Show undefined attributes

catalystActivity	[CatalystActivity:10720523] RNA endonuclease activity of C3PO [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10720525
displayName	C3PO hydrolyzes cleaved passenger strand
eventOf	[Pathway:R-XTR-426486] Small interfering RNA (siRNA) biogenesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-426520] Endonucleolytic RISC hydrolyzes target RNAs - Xenopus tropicalis [Reaction:R-XTR-426489] RISC binds inexactly matching target RNAs - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-9023909] C3PO hydrolyzes cleaved passenger strand - Homo sapiens
input	[Complex:R-XTR-9023915] AGO2:cleaved duplex siRNA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	C3PO hydrolyzes cleaved passenger strand
output	[Complex:R-XTR-2106601] AGO2:siRNA [cytosol]
precedingEvent	[BlackBoxEvent:R-XTR-2106625] Duplex siRNA is loaded into Argonaute - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-9023909
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-426486] Small interfering RNA (siRNA) biogenesis
(precedingEvent)	[Reaction:R-XTR-426489] RISC binds inexactly matching target RNAs [Reaction:R-XTR-426520] Endonucleolytic RISC hydrolyzes target RNAs
(inferredTo)	[Reaction:R-HSA-9023909] C3PO hydrolyzes cleaved passenger strand

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