Reactome | ADRB2:GRK complex dissociates to Phosphorylated ADRB2

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ADRB2:GRK complex dissociates to Phosphorylated ADRB2 Show undefined attributes

category	dissociation
compartment	[Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10718854
displayName	ADRB2:GRK complex dissociates to Phosphorylated ADRB2
eventOf	[Pathway:R-XTR-418555] G alpha (s) signalling events - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-8852167] ADRB2:Catecholamine binds ARRB1, ARRB2 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2 - Homo sapiens
input	[Complex:R-XTR-8982648] pS-ADRB2:Catecholamine:GRK [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	ADRB2:GRK complex dissociates to Phosphorylated ADRB2
output	[DefinedSet:R-XTR-8852026] GRK2, GRK3, GRK5, GRK6 [plasma membrane] [Complex:R-XTR-8852152] pS-ADRB2:Catecholamine [plasma membrane]
precedingEvent	[Reaction:R-XTR-8851797] ADRB2 in ADRB2:GRK complex is phosphorylated - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8982641
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-418555] G alpha (s) signalling events
(precedingEvent)	[Reaction:R-XTR-8852167] ADRB2:Catecholamine binds ARRB1, ARRB2
(inferredTo)	[Reaction:R-HSA-8982641] ADRB2:GRK complex dissociates to Phosphorylated ADRB2

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