Reactome | CBR3 reduces DOX to DOXOL

Schema > Reaction > Entries

catalystActivity	[CatalystActivity:10715849] carbonyl reductase (NADPH) activity of CBR3 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10715851
displayName	CBR3 reduces DOX to DOXOL
eventOf	[Pathway:R-XTR-211945] Phase I - Functionalization of compounds - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-8937419] CBR3 reduces DOX to DOXOL - Homo sapiens
input	[ChemicalDrug:R-ALL-9659674] doxorubicin [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CBR3 reduces DOX to DOXOL
output	[SimpleEntity:R-ALL-8937418] DOXOL [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8937419
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-211945] Phase I - Functionalization of compounds
(inferredTo)	[Reaction:R-HSA-8937419] CBR3 reduces DOX to DOXOL

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