Reactome | SLC36A4 transports L-Trp from extracellular region to cytosol

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SLC36A4 transports L-Trp from extracellular region to cytosol Show undefined attributes

catalystActivity	[CatalystActivity:10714480] L-tryptophan transmembrane transporter activity of SLC36A4 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10714482
displayName	SLC36A4 transports L-Trp from extracellular region to cytosol
eventOf	[Pathway:R-XTR-71240] Tryptophan catabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-888614] IDO2 dioxygenates L-Trp to NFK - Xenopus tropicalis [Reaction:R-XTR-71188] TDO tetramer dioxygenates L-Trp to NFK - Xenopus tropicalis
goBiologicalProcess	[GO_BiologicalProcess:6792321] L-tryptophan transmembrane transport
inferredFrom	[Reaction:R-HSA-8870352] SLC36A4 transports L-Trp from extracellular region to cytosol - Homo sapiens
input	[SimpleEntity:R-ALL-352006] L-Trp [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC36A4 transports L-Trp from extracellular region to cytosol L-tryptophan(in) = L-tryptophan(out)
output	[SimpleEntity:R-ALL-29500] L-Trp [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8870352
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-71240] Tryptophan catabolism
(precedingEvent)	[Reaction:R-XTR-888614] IDO2 dioxygenates L-Trp to NFK [Reaction:R-XTR-71188] TDO tetramer dioxygenates L-Trp to NFK
(inferredTo)	[Reaction:R-HSA-8870352] SLC36A4 transports L-Trp from extracellular region to cytosol

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