Reactome | SLC22A13 exchanges extracellular NCA for cytosolic urate

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SLC22A13 exchanges extracellular NCA for cytosolic urate Show undefined attributes

catalystActivity	[CatalystActivity:10714444] nicotinate transmembrane transporter activity of SLC22A13 [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane [Compartment:984] extracellular region [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10714446
displayName	SLC22A13 exchanges extracellular NCA for cytosolic urate
eventOf	[Pathway:R-XTR-196807] Nicotinate metabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:259346] NAD+ biosynthetic process via the salvage pathway
inferredFrom	[Reaction:R-HSA-8869603] SLC22A13 exchanges extracellular NCA for cytosolic urate - Homo sapiens
input	[SimpleEntity:R-ALL-8869604] NCA [extracellular region] [SimpleEntity:R-ALL-30034] urate [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC22A13 exchanges extracellular NCA for cytosolic urate nicotinate(in) + urate(out) = nicotinate(out) + urate(in)
output	[SimpleEntity:R-ALL-197230] NCA [cytosol] [SimpleEntity:R-ALL-429056] urate [extracellular region]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8869603
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-196807] Nicotinate metabolism
(inferredTo)	[Reaction:R-HSA-8869603] SLC22A13 exchanges extracellular NCA for cytosolic urate

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