Reactome | MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3

Schema > Reaction > Entries

MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 Show undefined attributes

catalystActivity	[CatalystActivity:10712973] alpha-mannosidase activity of MAN2B1:Zn2+ [lysosomal lumen]
category	transition
compartment	[Compartment:161320] lysosomal lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10712975
displayName	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3
eventOf	[Pathway:R-XTR-8853383] Lysosomal oligosaccharide catabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-8853686] MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3 - Homo sapiens
input	[SimpleEntity:R-ALL-8853396] alpha-D-Man-(1->3)-[alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc [lysosomal lumen] [SimpleEntity:R-ALL-1605715] H2O [lysosomal lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3
output	[SimpleEntity:R-ALL-6799577] alpha-D-Man-(1->3)-[alpha-D-Man-(1->6)]-beta-D-Man-(1->4)-beta-D-GlcNAc [lysosomal lumen] 2 × [SimpleEntity:R-ALL-6799594] Man [lysosomal lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-8853686
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8853383] Lysosomal oligosaccharide catabolism
(precedingEvent)	[Reaction:R-XTR-6799581] MAN2B2 hydrolyses GlcNAc (Man)3 to GlcNAc:Man
(inferredTo)	[Reaction:R-HSA-8853686] MAN2B1 hydrolyses GlcNAc (Man)5 to GlcNAc (Man)3

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