Reactome | Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

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Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP Show undefined attributes

category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10656032
displayName	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
eventOf	[Pathway:R-XTR-75953] RNA Polymerase II Transcription Initiation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-75864] Newly Formed Phosphodiester Bond Stabilized and PPi Released - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP - Homo sapiens
input	[Complex:R-XTR-83551] Pol II initiation complex [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP
output	[Complex:R-XTR-83601] Pol II Initiation complex with phosphodiester-PPi intermediate [nucleoplasm]
precedingEvent	[Reaction:R-XTR-75861] NTP Binds Active Site of RNA Polymerase II - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-75866
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-75953] RNA Polymerase II Transcription Initiation
(precedingEvent)	[Reaction:R-XTR-75864] Newly Formed Phosphodiester Bond Stabilized and PPi Released
(inferredTo)	[Reaction:R-HSA-75866] Nucleophillic Attack by 3'-hydroxyl Oxygen of nascent transcript on the Alpha Phosphate of NTP

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