Reactome | Insulin degradation

Schema > BlackBoxEvent > Entries

catalystActivity	[CatalystActivity:10655380] endopeptidase activity of IDE, CTSD [endosome lumen]
category	omitted
compartment	[Compartment:17940] endosome
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10655382
displayName	Insulin degradation
eventOf	[Pathway:R-XTR-77387] Insulin receptor recycling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-74730] Insulin degradation - Homo sapiens
input	[Complex:R-XTR-77385] insulin [endosome lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Insulin degradation
precedingEvent	[Reaction:R-XTR-74726] Dissociation of insulin from insulin receptor - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-74730
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-77387] Insulin receptor recycling
(inferredTo)	[BlackBoxEvent:R-HSA-74730] Insulin degradation

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