Reactome | (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)

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(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) Show undefined attributes

catalystActivity	[CatalystActivity:10654551] nucleoside kinase activity of DCK dimer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10654553
displayName	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)
eventOf	[Pathway:R-XTR-73614] Pyrimidine salvage - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-73596] dCMP + H2O => dUMP + NH4+ - Xenopus tropicalis [Reaction:R-XTR-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1) - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [DefinedSet:R-ALL-500829] Cyt-Rib, dC [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	(2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK) cytidine + ATP => CMP + ADP + H(+) 2'-deoxycytidine + ATP => dCMP + ADP + H(+) phosphorylation of 2'-Deoxycytidine to 2'-Deoxycytidine 5'-phosphate
output	[DefinedSet:R-ALL-500828] (d)CMP [cytosol] [SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-73598
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(precedingEvent)	[Reaction:R-XTR-73596] dCMP + H2O => dUMP + NH4+ [Reaction:R-XTR-73548] (d)CMP or UMP + ATP <=> (d)CDP or UDP + ADP (CMPK1)
(hasEvent)	[Pathway:R-XTR-73614] Pyrimidine salvage
(inferredTo)	[Reaction:R-HSA-73598] (2'-deoxy)cytidine + ATP => (d)CMP + ADP (DCK)

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