Reactome | PRODH oxidises L-Pro to 1PYR-5COOH

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PRODH oxidises L-Pro to 1PYR-5COOH Show undefined attributes

catalystActivity	[CatalystActivity:10652882] oxidoreductase activity, acting on the CH-NH group of donors, quinone or similar compound as acceptor of PRODH [mitochondrial inner membrane]
category	transition
compartment	[Compartment:5460] mitochondrial matrix [Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652884
displayName	PRODH oxidises L-Pro to 1PYR-5COOH
eventOf	[Pathway:R-XTR-70688] Proline catabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-70670] PRODH oxidises L-Pro to 1PYR-5COOH - Homo sapiens
input	[SimpleEntity:R-ALL-113597] FAD [mitochondrial inner membrane] [SimpleEntity:R-ALL-379717] L-Pro [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PRODH oxidises L-Pro to 1PYR-5COOH a quinone + L-proline => (S)-1-pyrroline-5-carboxylate + a quinol + H(+) proline => L-1-pyrroline-5-carboxylate
output	[SimpleEntity:R-ALL-113590] 1PYR-5COOH [mitochondrial matrix] [SimpleEntity:R-ALL-164934] FADH2 [mitochondrial inner membrane] 2 × [SimpleEntity:R-ALL-113529] H+ [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70670
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70688] Proline catabolism
(inferredTo)	[Reaction:R-HSA-70670] PRODH oxidises L-Pro to 1PYR-5COOH

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