Reactome | glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

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glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] Show undefined attributes

catalystActivity	[CatalystActivity:10652838] glutamine synthetase activity of GLUL decamer [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652840
displayName	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]
eventOf	[Pathway:R-XTR-210455] Astrocytic Glutamate-Glutamine Uptake And Metabolism - Xenopus tropicalis [Pathway:R-XTR-8964539] Glutamate and glutamine metabolism - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine - Xenopus tropicalis [Reaction:R-XTR-212614] Glutamine transport from astrocytes - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] - Homo sapiens
input	[SimpleEntity:R-ALL-113592] ATP [cytosol] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] [SimpleEntity:R-ALL-31633] NH4+ [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL] ATP + L-glutamate + NH4(+) => ADP + H(+) + L-glutamine + phosphate
output	[SimpleEntity:R-ALL-29370] ADP [cytosol] [SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29472] L-Gln [cytosol] [SimpleEntity:R-ALL-29372] Pi [cytosol]
precedingEvent	[Reaction:R-XTR-210439] glutamate uptake by astrocytes - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70606
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-8964539] Glutamate and glutamine metabolism [Pathway:R-XTR-210455] Astrocytic Glutamate-Glutamine Uptake And Metabolism
(precedingEvent)	[Reaction:R-XTR-893616] glutamine + pyruvate => 2-oxoglutaramate + alanine [Reaction:R-XTR-212614] Glutamine transport from astrocytes
(inferredTo)	[Reaction:R-HSA-70606] glutamate + NH4+ + ATP => glutamine + ADP + orthophosphate [GLUL]

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