Reactome | PCK1 phosphorylates OA to yield PEP

Schema > Reaction > Entries

PCK1 phosphorylates OA to yield PEP Show undefined attributes

catalystActivity	[CatalystActivity:10652504] phosphoenolpyruvate carboxykinase (GTP) activity of PCK1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10652506
displayName	PCK1 phosphorylates OA to yield PEP
eventOf	[Pathway:R-XTR-70263] Gluconeogenesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-70241] PCK1 phosphorylates OA to yield PEP - Homo sapiens
input	[SimpleEntity:R-ALL-29438] GTP [cytosol] [SimpleEntity:R-ALL-76213] OA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	PCK1 phosphorylates OA to yield PEP GTP + oxaloacetate => CO2 + GDP + phosphoenolpyruvate
output	[SimpleEntity:R-ALL-113528] CO2 [cytosol] [SimpleEntity:R-ALL-29420] GDP [cytosol] [SimpleEntity:R-ALL-29492] PEP [cytosol]
precedingEvent	[Reaction:R-XTR-70592] PXLP-K259-GOT1 transaminates 2-OG and L-Asp - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-70241
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-70263] Gluconeogenesis
(precedingEvent)	[Reaction:R-XTR-70494] Enolase dimers (ENO1,2,3) convert PEP to 2PG
(inferredTo)	[Reaction:R-HSA-70241] PCK1 phosphorylates OA to yield PEP

Cite Us!