Reactome | SETD9 methylates TP53

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SETD9 methylates TP53 Show undefined attributes

catalystActivity	[CatalystActivity:10710197] lysine N-methyltransferase activity of SETD9 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10710199
displayName	SETD9 methylates TP53
eventOf	[Pathway:R-XTR-6804760] Regulation of TP53 Activity through Methylation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6805730] SETD9 methylates TP53 - Homo sapiens
input	4 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-XTR-3222171] p-S15,S20-TP53 Tetramer [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	SETD9 methylates TP53
output	4 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-XTR-6805731] Me1-K372,p-S15,S20-TP53 Tetramer [nucleoplasm]
precedingEvent	[Reaction:R-XTR-69685] CHEK2 phosphorylates TP53 - Xenopus tropicalis [Reaction:R-XTR-6805285] PLK3 phosphorylates TP53 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6805730
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6804760] Regulation of TP53 Activity through Methylation
(inferredTo)	[Reaction:R-HSA-6805730] SETD9 methylates TP53