Reactome | APAF1:CYCS binds APIP

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10709651
displayName	APAF1:CYCS binds APIP
eventOf	[Pathway:R-XTR-9627069] Regulation of the apoptosome activity - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-6804596] APAF1:CYCS binds APIP - Homo sapiens
input	[Complex:R-XTR-6804619] APAF1:ATP:CYCS heptamer:CASP9 [cytosol] [EntityWithAccessionedSequence:R-XTR-1237171] APIP [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	APAF1:CYCS binds APIP
output	[Complex:R-XTR-6804605] APAF1:CYCS:ATP:APIP [cytosol]
precedingEvent	[Reaction:R-XTR-114256] CYCS:APAF1 binds procaspase-9 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6804596
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-9627069] Regulation of the apoptosome activity
(inferredTo)	[Reaction:R-HSA-6804596] APAF1:CYCS binds APIP

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