Reactome | COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex

Schema > Reaction > Entries

COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex Show undefined attributes

category	binding
compartment	[Compartment:70616] mitochondrial inner membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10708551
displayName	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
eventOf	[Pathway:R-XTR-6799198] Complex I biogenesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex - Homo sapiens
input	[Complex:R-XTR-9708004] COA1:MT-ND2 [mitochondrial inner membrane] [Complex:R-XTR-5689052] MCIA complex [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-XTR-60569] mt-nd6 [mitochondrial inner membrane] [EntityWithAccessionedSequence:R-XTR-59938] ndufb6 [mitochondrial inner membrane] [Complex:R-XTR-9708002] TMEM186:MT-ND3 [mitochondrial inner membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex
output	[Complex:R-XTR-6799190] 370 kDa subcomplex [mitochondrial inner membrane]
regulatedBy	[Requirement:10708552] Requirement by 'FOXRED1 [mitochondrial inner membrane]' [Requirement:10708553] Requirement by 'SFXN4 [mitochondrial inner membrane]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6799199
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-6799198] Complex I biogenesis
(precedingEvent)	[Reaction:R-XTR-6799202] The 315kDa subcomplex binds the 370kDa subcomplex to form the 550kDa complex
(inferredTo)	[Reaction:R-HSA-6799199] COA1:MT-ND2, TMEM186:MT-ND3, MT-ND6, NDUFB6 bind the MCIA complex to form a 370kDa subcomplex

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