Reactome | ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]

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ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] Show undefined attributes

compartment	[Compartment:7660] nucleoplasm
componentOf	[Complex:R-XTR-6782122] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-6781842] ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-6782230] TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] - Xenopus tropicalis [Complex:R-XTR-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10705043
displayName	ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
hasComponent	[DefinedSet:R-XTR-976081] CUL4 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-53489] ddb1 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-52835] ercc8 [nucleoplasm] [EntityWithAccessionedSequence:R-XTR-1234142] rbx1 [nucleoplasm]
inDisease	false
inferredFrom	[Complex:R-HSA-6781841] ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] - Homo sapiens
maxDepth	3
name	ERCC8:DDB1:CUL4:RBX1
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-6781841
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

Referrals

(hasComponent)	[Complex:R-XTR-6782230] TC-NER post-incision complex:dsDNA with transcription bubble [nucleoplasm] [Complex:R-XTR-6782220] TC-NER post-incision complex:SSB-dsDNA:trimmed nascent mRNA: (PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-XTR-6782222] TC-NER post-incision complex:incised DNA without lesion:trimmed nascent mRNA:PCNA:(PCNA:POLD,POLE),(MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-XTR-6782219] TC-NER incision complex: 5'-incised damaged DNA:trimmed nascent mRNA:(PCNA:POLD,POLE), (MonoUb:K164-PCNA:POLK):RPA:RFC [nucleoplasm] [Complex:R-XTR-6782205] TC-NER incision complex:5'-incised damaged DNA:trimmed nascent mRNA [nucleoplasm] [Complex:R-XTR-6782122] Ubiquitinated,hyperphosphorylated RNA Pol II:Open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-XTR-9684121] Ubiquitinated,hyperphosphorylated RNA Pol II:Partially open bubble damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-XTR-6782068] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-XTR-6781866] Ubiquitinated,hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:Ub:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-XTR-6781839] Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm] [Complex:R-XTR-6781842] ERCC8:DDB1:CUL4:RBX1:COP9 Signalosome [nucleoplasm]
(activeUnit)	[CatalystActivity:10705067] ubiquitin protein ligase activity of Hyperphosphorylated RNA Pol II:Damaged DNA template:nascent mRNA hybrid:TFIIH:ERCC6:ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]
(inferredTo)	[Complex:R-HSA-6781841] ERCC8:DDB1:CUL4:RBX1 [nucleoplasm]

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