Reactome | p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 Show undefined attributes

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10699894
displayName	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
eventOf	[Pathway:R-XTR-5628897] TP53 Regulates Metabolic Genes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4 - Homo sapiens
input	[DefinedSet:R-XTR-1445138] 14-3-3 dimer [cytosol] [EntityWithAccessionedSequence:R-XTR-199484] phospho-tsc2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4
output	[Complex:R-XTR-5632727] p-S939,T1462-TSC2:14-3-3 dimer [cytosol]
regulatedBy	[NegativeRegulation:10699895] Negative regulation by 'DDIT4:14-3-3 dimer [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5632732
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5628897] TP53 Regulates Metabolic Genes
(inferredTo)	[Reaction:R-HSA-5632732] p-S939,T1462-TSC2 binding to 14-3-3 dimer is negatively regulated by DDIT4

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