Reactome | CYP26A1,B1,C1 4-hydroxylate atRA

Schema > Reaction > Entries

CYP26A1,B1,C1 4-hydroxylate atRA Show undefined attributes

catalystActivity	[CatalystActivity:10667382] retinoic acid 4-hydroxylase activity of CYP26A1,B1,C1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10697596
displayName	CYP26A1,B1,C1 4-hydroxylate atRA
eventOf	[Pathway:R-XTR-5365859] RA biosynthesis pathway - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-5362525] CYP26A1,B1,C1 4-hydroxylate atRA - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [Complex:R-XTR-5622116] SUMO-CRABP1:atRA [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP26A1,B1,C1 4-hydroxylate atRA
output	[SimpleEntity:R-ALL-5362521] 4OH-atRA [cytosol] [EntityWithAccessionedSequence:R-XTR-5334807] crabp1 [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
precedingEvent	[Reaction:R-XTR-5622134] CRABP1 binds atRA - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5362525
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5365859] RA biosynthesis pathway
(inferredTo)	[Reaction:R-HSA-5362525] CYP26A1,B1,C1 4-hydroxylate atRA