Reactome | P4HB forms mixed disulphides with Hh precursors

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P4HB forms mixed disulphides with Hh precursors Show undefined attributes

category	binding
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10697374
displayName	P4HB forms mixed disulphides with Hh precursors
eventOf	[Pathway:R-XTR-5358346] Hedgehog ligand biogenesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-5358340] Autoproteolytic cleavage of Hh precursors - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-5358336] P4HB forms mixed disulphides with Hh precursors - Homo sapiens
input	[CandidateSet:R-XTR-5362382] NglycoAsn-Hh precursors [endoplasmic reticulum lumen] [EntityWithAccessionedSequence:R-XTR-174692] p4hb [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	P4HB forms mixed disulphides with Hh precursors
output	[Complex:R-XTR-5490380] NglycoAsn-Hh precursors:P4HB [endoplasmic reticulum lumen]
precedingEvent	[BlackBoxEvent:R-XTR-5362386] Glycosylation of Hh - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-5358336
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-5358346] Hedgehog ligand biogenesis
(precedingEvent)	[Reaction:R-XTR-5358340] Autoproteolytic cleavage of Hh precursors
(inferredTo)	[Reaction:R-HSA-5358336] P4HB forms mixed disulphides with Hh precursors

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