Reactome | Addition of the first glucose to the N-glycan precursor by ALG6

Schema > Reaction > Entries

Addition of the first glucose to the N-glycan precursor by ALG6 Show undefined attributes

catalystActivity	[CatalystActivity:10675637] dolichyl-phosphate-glucose-glycolipid alpha-glucosyltransferase activity of ALG6 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10675639
displayName	Addition of the first glucose to the N-glycan precursor by ALG6
eventOf	[Pathway:R-XTR-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-446189] Addition of a second glucose to the N-glycan precursor by ALG8 - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-446202] Addition of the first glucose to the N-glycan precursor by ALG6 - Homo sapiens
input	[SimpleEntity:R-ALL-449371] (GlcNAc)2 (Man)9 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-532542] DbGP [lumenal side of endoplasmic reticulum membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Addition of the first glucose to the N-glycan precursor by ALG6
output	[SimpleEntity:R-ALL-449649] (Glc)1 (GlcNAc)2 (Man)9 (PP-Dol)1 [lumenal side of endoplasmic reticulum membrane] [SimpleEntity:R-ALL-449311] DOLP [lumenal side of endoplasmic reticulum membrane]
precedingEvent	[Reaction:R-XTR-446216] ALG9 transfers Man to N-glycan precursor (GlcNAc)2 (Man)8 (PP-Dol)1 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-446202
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-446193] Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
(precedingEvent)	[Reaction:R-XTR-446189] Addition of a second glucose to the N-glycan precursor by ALG8
(inferredTo)	[Reaction:R-HSA-446202] Addition of the first glucose to the N-glycan precursor by ALG6