Reactome | Gi,Go Heterotrimeric G-protein complex dissociates

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Gi,Go Heterotrimeric G-protein complex dissociates Show undefined attributes

catalystActivity	[CatalystActivity:10672459] guanyl-nucleotide exchange factor activity of G alpha (i,o) (candidates) [plasma membrane]
category	transition
compartment	[Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10672461
displayName	Gi,Go Heterotrimeric G-protein complex dissociates
eventOf	[Pathway:R-XTR-400042] Adrenaline,noradrenaline inhibits insulin secretion - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-400097] G-beta:G-gamma inhibits Adenylate cyclase - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-400037] Gi,Go Heterotrimeric G-protein complex dissociates - Homo sapiens
input	[Complex:R-XTR-400031] G-alpha(i,o):GTP:G-beta:G-gamma [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Gi,Go Heterotrimeric G-protein complex dissociates
output	[Complex:R-XTR-400076] G-alpha(i,o):GTP [plasma membrane] [Complex:R-XTR-400034] G-beta:G-gamma (candidates) [plasma membrane]
precedingEvent	[Reaction:R-XTR-400092] Alpha-2A,alpha-2C Adrenergic Receptors activate Gi.Go heterotrimeric G proteins - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-400037
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-400042] Adrenaline,noradrenaline inhibits insulin secretion
(precedingEvent)	[Reaction:R-XTR-400097] G-beta:G-gamma inhibits Adenylate cyclase
(inferredTo)	[Reaction:R-HSA-400037] Gi,Go Heterotrimeric G-protein complex dissociates

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