Reactome | EPHB-mediated forward signaling

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EPHB-mediated forward signaling Show undefined attributes

compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10730662
displayName	EPHB-mediated forward signaling
eventOf	[Pathway:R-XTR-2682334] EPH-Ephrin signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-3928592] p190RhoGEF exchanges GTP for GDP on RHOA, activating it - Xenopus tropicalis [Reaction:R-XTR-3928576] RHOA:GTP binds ROCK, activating it - Xenopus tropicalis [Reaction:R-XTR-3928645] EPHB:NMDAR binds TIAM1 - Xenopus tropicalis [Reaction:R-XTR-3928627] EPHB phosphorylates TIAM1 - Xenopus tropicalis [Reaction:R-XTR-4093339] p120-RasGAP activates GTP hydrolysis on RAS, inactivating it - Xenopus tropicalis [Reaction:R-XTR-4093332] p-EPHB phosphorylates SDC2 - Xenopus tropicalis [BlackBoxEvent:R-XTR-4093342] SDC2 multimerises - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	EPHB-mediated forward signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3928662
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2682334] EPH-Ephrin signaling
(inferredTo)	[Pathway:R-HSA-3928662] EPHB-mediated forward signaling

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