Reactome | Co-inhibition by CTLA4

Schema > Pathway > Entries

created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729794
displayName	Co-inhibition by CTLA4
eventOf	[Pathway:R-XTR-388841] Regulation of T cell activation by CD28 family - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-389532] PP2A binds CTLA4 dimer - Xenopus tropicalis [Reaction:R-XTR-388809] CTLA-4 binds B7-1/B7-2 - Xenopus tropicalis [Reaction:R-XTR-388833] Phosphorylation of CTLA-4 - Xenopus tropicalis [Reaction:R-XTR-388829] SHP2 phosphatase binds CTLA-4 - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-389513] Co-inhibition by CTLA4 - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Co-inhibition by CTLA4 CTLA4 inhibitory signaling
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-389513
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-388841] Regulation of T cell activation by CD28 family
(inferredTo)	[Pathway:R-HSA-389513] Co-inhibition by CTLA4

Cite Us!