Reactome | Glucagon-like Peptide 1 is secreted from intestinal L cells

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Glucagon-like Peptide 1 is secreted from intestinal L cells Show undefined attributes

category	omitted
compartment	[Compartment:984] extracellular region [Compartment:1462052] secretory granule lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10671503
displayName	Glucagon-like Peptide 1 is secreted from intestinal L cells
eventOf	[Pathway:R-XTR-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-421419] gcg [secretory granule lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Glucagon-like Peptide 1 is secreted from intestinal L cells
output	[EntityWithAccessionedSequence:R-XTR-381699] gcg [extracellular region]
regulatedBy	[PositiveRegulation:10671504] Positive regulation by 'LEP [extracellular region]' [PositiveRegulation:R-HSA-400545] Positive regulation by 'AcCho [extracellular region]' [PositiveRegulation:R-HSA-400558] Positive regulation by 'Glc [extracellular region]'
releaseDate	2026-03-25
schemaClass	BlackBoxEvent
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-383313
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-381771] Synthesis, secretion, and inactivation of Glucagon-like Peptide-1 (GLP-1)
(inferredTo)	[BlackBoxEvent:R-HSA-383313] Glucagon-like Peptide 1 is secreted from intestinal L cells

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