Reactome | Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Show undefined attributes

compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729776
displayName	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)
eventOf	[TopLevelPathway:R-XTR-392499] Metabolism of proteins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
hasDiagram	true
hasEHLD	false
hasEvent	[Reaction:R-XTR-381487] IGFBP1 binds IGF forming IGF:IGFBP1 - Xenopus tropicalis [Reaction:R-XTR-381412] IGFBP2 binds IGF forming IGF:IGFBP2 - Xenopus tropicalis [Reaction:R-XTR-381543] IGFBP4 binds IGF forming IGF:IGFBP4 - Xenopus tropicalis [Reaction:R-XTR-381518] PAAP-A proteolyzes IGF:IGFBP4 - Xenopus tropicalis [Reaction:R-XTR-8952289] FAM20C phosphorylates FAM20C substrates - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs) Regulation of IGF Activity by IGFBP
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-381426
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[TopLevelPathway:R-XTR-392499] Metabolism of proteins
(hasEncapsulatedEvent)	[Pathway:R-XTR-5633008] TP53 Regulates Transcription of Cell Death Genes [Pathway:R-XTR-5625886] Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3
(inferredTo)	[Pathway:R-HSA-381426] Regulation of Insulin-like Growth Factor (IGF) transport and uptake by Insulin-like Growth Factor Binding Proteins (IGFBPs)

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