Reactome | EHMT1:EHMT2 methylates IL8 promoter

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EHMT1:EHMT2 methylates IL8 promoter Show undefined attributes

catalystActivity	[CatalystActivity:10694263] histone H3 methyltransferase activity of EHMT1:EHMT2 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10694265
displayName	EHMT1:EHMT2 methylates IL8 promoter
eventOf	[Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3788745] EHMT1:EHMT2 methylates IL8 promoter - Homo sapiens
input	4 × [SimpleEntity:R-ALL-77087] AdoMet [nucleoplasm] [Complex:R-XTR-3788743] IL8 gene:Nucleosome [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	EHMT1:EHMT2 methylates IL8 promoter
output	4 × [SimpleEntity:R-ALL-77502] AdoHcy [nucleoplasm] [Complex:R-XTR-3788746] IL8 gene:Nucleosome-H3K9Me2 [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3788745
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2559582] Senescence-Associated Secretory Phenotype (SASP)
(inferredTo)	[Reaction:R-HSA-3788745] EHMT1:EHMT2 methylates IL8 promoter

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