Reactome | Dephosphorylation of inactive SRC by PTPB1

Schema > Reaction > Entries

Dephosphorylation of inactive SRC by PTPB1 Show undefined attributes

catalystActivity	[CatalystActivity:10669250] protein tyrosine phosphatase activity of PTPN1 [cytosol]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10669252
displayName	Dephosphorylation of inactive SRC by PTPB1
eventOf	[Pathway:R-XTR-354192] Integrin signaling - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-377640] Autophosphorylation of SRC - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1 - Homo sapiens
input	2 × [SimpleEntity:R-ALL-29356] H2O [cytosol] [Complex:R-XTR-377616] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:Inactive (p-Y530)-SRC) [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	Dephosphorylation of inactive SRC by PTPB1
output	2 × [SimpleEntity:R-ALL-29372] Pi [cytosol] [Complex:R-XTR-377620] Talin:RIAM complex:ECM ligands: 2X(Integrin alphaIIb beta3:SRC) [plasma membrane]
precedingEvent	[Reaction:R-XTR-377644] Release of CSK from SRC - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-377643
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-354192] Integrin signaling
(precedingEvent)	[Reaction:R-XTR-377640] Autophosphorylation of SRC
(inferredTo)	[Reaction:R-HSA-377643] Dephosphorylation of inactive SRC by PTPB1

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