Reactome | PP2A (Aalpha:B55alpha:Calpha) [cytosol]

Schema > Complex > Entries

compartment	[Compartment:70101] cytosol
componentOf	[Complex:R-XTR-927845] mRNA Cleaved by SMG6 [cytosol] - Xenopus tropicalis [Complex:R-XTR-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] - Xenopus tropicalis
consumedByEvent	[BlackBoxEvent:R-XTR-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A - Xenopus tropicalis [Reaction:R-XTR-9667965] ANKLE2 binds PP2A - Xenopus tropicalis
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10678564
displayName	PP2A (Aalpha:B55alpha:Calpha) [cytosol]
hasComponent	[EntityWithAccessionedSequence:R-XTR-165971] ppp2ca [cytosol] [EntityWithAccessionedSequence:R-XTR-165982] ppp2r1a [cytosol] [EntityWithAccessionedSequence:R-XTR-377253] ppp2r2a [cytosol]
inDisease	false
inferredFrom	[Complex:R-HSA-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol] - Homo sapiens
isRequired	[Requirement:10678628] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]'
maxDepth	2
name	PP2A (Aalpha:B55alpha:Calpha)
positivelyRegulates	[Requirement:10678628] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]'
producedByEvent	[BlackBoxEvent:R-XTR-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex - Xenopus tropicalis
schemaClass	Complex
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-377182
summation	[Summation:9984903] This complex/polymer has been computationally inferred (based on PANTHER) from a complex/polymer involved in an event that has been demonstrated in another species.

(regulator)	[Requirement:10678628] Requirement by 'PP2A (Aalpha:B55alpha:Calpha) [cytosol]'
(output)	[BlackBoxEvent:R-XTR-927830] Decay of mRNA in SMG6:SMG5:SMG7:mRNA complex
(input)	[BlackBoxEvent:R-XTR-927813] p-4S-UPF1 recruits SMG5, SMG7, SMG6, PNRC2, DCP1A, and PP2A [Reaction:R-XTR-9667965] ANKLE2 binds PP2A
(hasComponent)	[Complex:R-XTR-927845] mRNA Cleaved by SMG6 [cytosol] [Complex:R-XTR-927854] Phosphorylated UPF1:SMG5:SMG7:SMG6:PP2A:Translated mRNP [cytosol] [Complex:R-XTR-9667967] ANKLE2:PP2A [endoplasmic reticulum membrane]
(activeUnit)	[CatalystActivity:10692181] protein serine/threonine phosphatase activity of ANKLE2:PP2A [endoplasmic reticulum membrane]
(inferredTo)	[Complex:R-HSA-377182] PP2A (Aalpha:B55alpha:Calpha) [cytosol]