Reactome | EP300 acetylates histone H2A, H2B, H3, H4

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EP300 acetylates histone H2A, H2B, H3, H4 Show undefined attributes

catalystActivity	[CatalystActivity:10693855] histone acetyltransferase activity of EP300 [nucleoplasm]
category	transition
compartment	[Compartment:7660] nucleoplasm
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10693857
displayName	EP300 acetylates histone H2A, H2B, H3, H4
eventOf	[Pathway:R-XTR-3214847] HATs acetylate histones - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-3662335] EP300 acetylates histone H2A, H2B, H3, H4 - Homo sapiens
input	[SimpleEntity:R-ALL-113560] Ac-CoA [nucleoplasm] [CandidateSet:R-XTR-4568580] Histone H2A, H2B, H3, H4 [nucleoplasm]
isInDisease	false
isInferred	true
maxDepth	1
name	EP300 acetylates histone H2A, H2B, H3, H4
output	[CandidateSet:R-XTR-4568601] AcK-histone H2A, H2B, H3, H4 [nucleoplasm] [SimpleEntity:R-ALL-2485002] CoA-SH [nucleoplasm]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-3662335
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-3214847] HATs acetylate histones
(inferredTo)	[Reaction:R-HSA-3662335] EP300 acetylates histone H2A, H2B, H3, H4

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