Reactome | Cho is acetylated to AcCho by CHAT

Schema > Reaction > Entries

Cho is acetylated to AcCho by CHAT Show undefined attributes

catalystActivity	[CatalystActivity:10667803] choline O-acetyltransferase activity of CHAT [cytosol]
category	transition
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10667805
displayName	Cho is acetylated to AcCho by CHAT
eventOf	[Pathway:R-XTR-264642] Acetylcholine Neurotransmitter Release Cycle - Xenopus tropicalis [Pathway:R-XTR-1483191] Synthesis of PC - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-264615] Loading of acetylcholine in synaptic vesicles - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-264622] Cho is acetylated to AcCho by CHAT - Homo sapiens
input	[SimpleEntity:R-ALL-76183] Ac-CoA [cytosol] [SimpleEntity:R-ALL-264618] Cho [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	Cho is acetylated to AcCho by CHAT Synthesis of o-acetylcholine
output	[SimpleEntity:R-ALL-264643] AcCho [cytosol] [SimpleEntity:R-ALL-76194] CoA-SH [cytosol]
precedingEvent	[Reaction:R-XTR-429594] SLC5A7 cotransports Cho, Cl-, Na+ from extracellular region to cytosol - Xenopus tropicalis [Reaction:R-XTR-1483182] PC is hydrolyzed to PA and choline by PLD1/2 - Xenopus tropicalis [Reaction:R-XTR-1483159] PCho is dephosphorylated to Cho by PHOSPHO1 - Xenopus tropicalis [Reaction:R-XTR-444433] Cho transports from the extracellular space to the cytosol - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-264622
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1483191] Synthesis of PC [Pathway:R-XTR-264642] Acetylcholine Neurotransmitter Release Cycle
(precedingEvent)	[Reaction:R-XTR-264615] Loading of acetylcholine in synaptic vesicles
(inferredTo)	[Reaction:R-HSA-264622] Cho is acetylated to AcCho by CHAT