Reactome | PDSS1,2 ligates FPP to IPPP

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PDSS1,2 ligates FPP to IPPP Show undefined attributes

catalystActivity	[CatalystActivity:10689229] all-trans-decaprenyl-diphosphate synthase activity of PDSS1/2 tetramer [mitochondrial matrix]
category	transition
compartment	[Compartment:5460] mitochondrial matrix
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10689231
displayName	PDSS1,2 ligates FPP to IPPP
eventOf	[Pathway:R-XTR-2142789] Ubiquinol biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2162192] COQ2 ligates all-E-10PrP2 to PHB - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-2162253] PDSS1,2 ligates FPP to IPPP - Homo sapiens
input	[SimpleEntity:R-ALL-2162257] FPP [mitochondrial matrix] 7 × [SimpleEntity:R-ALL-2162256] IPPP [mitochondrial matrix]
isInDisease	false
isInferred	true
maxDepth	1
name	PDSS1,2 ligates FPP to IPPP FPP and IPPP are combined into all-E-10PrP2 by PDSS1/2 tetramer
output	[SimpleEntity:R-ALL-2162214] all-E-10PrP2 [mitochondrial inner membrane] 7 × [SimpleEntity:R-ALL-159450] PPi [mitochondrial matrix]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2162253
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142789] Ubiquinol biosynthesis
(precedingEvent)	[Reaction:R-XTR-2162192] COQ2 ligates all-E-10PrP2 to PHB
(inferredTo)	[Reaction:R-HSA-2162253] PDSS1,2 ligates FPP to IPPP

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