Reactome | ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

Schema > Reaction > Entries

ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 Show undefined attributes

catalystActivity	[CatalystActivity:10689072] oxidoreductase activity, acting on single donors with incorporation of molecular oxygen, incorporation of two atoms of oxygen of ALOX5:ALOX5AP:LTC4S [nuclear envelope]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:13231] nuclear envelope
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10689074
displayName	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
eventOf	[Pathway:R-XTR-2142700] Biosynthesis of Lipoxins (LX) - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4 - Homo sapiens
input	[SimpleEntity:R-ALL-2142738] 15R-HETE [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4
output	[DefinedSet:R-ALL-2161609] 15epi-LXA4/B4 [cytosol]
precedingEvent	[Reaction:R-XTR-2161951] Arachidonate is oxidised to 15R-HETE by Acetyl-PTGS2 - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2161907
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-2142700] Biosynthesis of Lipoxins (LX)
(inferredTo)	[Reaction:R-HSA-2161907] ALOX5 oxidises 15R-HETE to 15epi-LXA4/B4

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