Reactome | CYP2D6 4-hydroxylates debrisoquine

Schema > Reaction > Entries

CYP2D6 4-hydroxylates debrisoquine Show undefined attributes

catalystActivity	[CatalystActivity:10667354] oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen of Cytochrome P450 (CYP2D6 based) [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:12045] endoplasmic reticulum membrane [Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10667356
displayName	CYP2D6 4-hydroxylates debrisoquine
eventOf	[Pathway:R-XTR-211981] Xenobiotics - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine - Homo sapiens
input	[SimpleEntity:R-ALL-211993] DSQ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-156540] H+ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113601] NADPH [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP2D6 4-hydroxylates debrisoquine
output	[SimpleEntity:R-ALL-113519] H2O [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-211952] HDBQ [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113564] NADP+ [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-211966
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-211981] Xenobiotics
(inferredTo)	[Reaction:R-HSA-211966] CYP2D6 4-hydroxylates debrisoquine