Reactome | SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+

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SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ Show undefined attributes

catalystActivity	[CatalystActivity:10667082] high-affinity L-glutamate transmembrane transporter activity of SLC1A1-3,6,7 [plasma membrane]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane [Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10667088
displayName	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+
eventOf	[Pathway:R-XTR-210500] Glutamate Neurotransmitter Release Cycle - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-210444] L-Glutamate loading of synaptic vesicle - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ - Homo sapiens
input	[SimpleEntity:R-ALL-351626] H+ [extracellular region] [SimpleEntity:R-ALL-29804] K+ [cytosol] [SimpleEntity:R-ALL-210382] L-Glu [extracellular region] 3 × [SimpleEntity:R-ALL-74113] Na+ [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+ L-Glutamate uptake by neurons
output	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-74126] K+ [extracellular region] [SimpleEntity:R-ALL-29404] L-Glu [cytosol] 3 × [SimpleEntity:R-ALL-83910] Na+ [cytosol]
regulatedBy	[NegativeRegulation:10667089] Negative regulation by 'ARL6IP5 [cytosol]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-210404
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-210500] Glutamate Neurotransmitter Release Cycle
(precedingEvent)	[Reaction:R-XTR-210444] L-Glutamate loading of synaptic vesicle
(inferredTo)	[Reaction:R-HSA-210404] SLC1A1-3,6,7 exchange L-Glu, H+ and 3Na+ for K+

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