Reactome | Serotonin and melatonin biosynthesis

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Serotonin and melatonin biosynthesis Show undefined attributes

compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10729610
displayName	Serotonin and melatonin biosynthesis
eventOf	[Pathway:R-XTR-209776] Metabolism of amine-derived hormones - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
goBiologicalProcess	[GO_BiologicalProcess:12114] indolalkylamine biosynthetic process
hasDiagram	false
hasEHLD	false
hasEvent	[Reaction:R-XTR-209859] Decarboxylation of 5-hydroxytryptophan forms serotonin - Xenopus tropicalis [Reaction:R-XTR-209792] N-acetylation of serotonin - Xenopus tropicalis [Reaction:R-XTR-209821] Methylation of N-acetyl-5-HT to form melatonin - Xenopus tropicalis
inferredFrom	[Pathway:R-HSA-209931] Serotonin and melatonin biosynthesis - Homo sapiens
isInDisease	false
isInferred	true
maxDepth	2
name	Serotonin and melatonin biosynthesis
releaseDate	2026-03-25
schemaClass	Pathway
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-209931
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-209776] Metabolism of amine-derived hormones
(inferredTo)	[Pathway:R-HSA-209931] Serotonin and melatonin biosynthesis

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