Reactome | Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))

catalystActivity	[CatalystActivity:10687556] aspartic-type endopeptidase activity of Renin [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10687558
displayName	Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))
eventOf	[Pathway:R-XTR-2022377] Metabolism of Angiotensinogen to Angiotensins - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-XTR-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-XTR-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) - Xenopus tropicalis [Reaction:R-XTR-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-XTR-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-XTR-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) - Xenopus tropicalis [Reaction:R-XTR-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) - Xenopus tropicalis
goBiologicalProcess	[GO_BiologicalProcess:172124] angiotensin maturation
inferredFrom	[Reaction:R-HSA-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) - Homo sapiens
input	[EntityWithAccessionedSequence:R-XTR-1998759] agt [extracellular region] [SimpleEntity:R-ALL-109276] H2O [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) Renin Hydrolyzes Angiotensinogen to Yield Angiotensin I
output	[EntityWithAccessionedSequence:R-XTR-2022346] agt [extracellular region]
regulatedBy	[NegativeRegulation:R-HSA-2022374] Negative regulation by 'aliskiren [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-2022412
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-2022377] Metabolism of Angiotensinogen to Angiotensins
(precedingEvent)	[Reaction:R-XTR-2022396] MME:Zn2+ (Neprilysin) hydrolyses AGT(25-34) (Angiotensin-(1-10)) to AGT(25-31) (Angiotensin-(1-7)) [Reaction:R-XTR-2022411] Cathepsin G hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-XTR-2022381] Cathepsin Z (Cathepsin X) hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-XTR-2022383] Chymase hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-XTR-2022378] ACE2(18-805):Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-33) (Angiotensin-(1-9)) [Reaction:R-XTR-2022405] ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8)) [Reaction:R-XTR-2065355] Secreted ACE:Zn2+ hydrolyzes AGT(25-34) (Angiotensin-(1-10)) to AGT(25-32) (Angiotensin-(1-8))
(inferredTo)	[Reaction:R-HSA-2022412] Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10))

Renin hydrolyzes Angiotensinogen to AGT(25-34) (Angiotensin-(1-10)) Show undefined attributes

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