Reactome | Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen

Schema > Reaction > Entries

Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen Show undefined attributes

catalystActivity	[CatalystActivity:10686354] procollagen-proline 3-dioxygenase activity of Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen]
category	transition
compartment	[Compartment:17957] endoplasmic reticulum lumen
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10686356
displayName	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen
eventOf	[Pathway:R-XTR-1650814] Collagen biosynthesis and modifying enzymes - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen - Homo sapiens
input	[SimpleEntity:R-ALL-1650779] 2OG [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-113534] O2 [endoplasmic reticulum lumen] [Complex:R-XTR-8948233] Prolyl 3-hydroxylases:Fe2+:4-Hyp collagen propeptides [endoplasmic reticulum lumen]
isInDisease	false
isInferred	true
maxDepth	1
name	Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen
output	[SimpleEntity:R-ALL-159751] CO2 [endoplasmic reticulum lumen] [Complex:R-XTR-2022426] Prolyl 3-hydroxylases:Fe2+:3,4-Hyp collagen propeptides [endoplasmic reticulum lumen] [SimpleEntity:R-ALL-1650769] SUCCA [endoplasmic reticulum lumen]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1980233
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1650814] Collagen biosynthesis and modifying enzymes
(inferredTo)	[Reaction:R-HSA-1980233] Collagen prolyl 3-hydroxylase converts 4-Hyp collagen to 3,4-Hyp collagen

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