Reactome | ITCH binds DTX

Schema > Reaction > Entries

category	binding
compartment	[Compartment:70101] cytosol
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10686203
displayName	ITCH binds DTX
eventOf	[Pathway:R-XTR-2122948] Activated NOTCH1 Transmits Signal to the Nucleus - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-1912357] ITCH ubiquitinates DTX - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-1980125] ITCH binds DTX - Homo sapiens
input	[CandidateSet:R-XTR-1604454] DTX [cytosol] [EntityWithAccessionedSequence:R-XTR-975995] itch [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	ITCH binds DTX
output	[Complex:R-XTR-1604453] DTX:ITCH [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1980125
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

(hasEvent)	[Pathway:R-XTR-2122948] Activated NOTCH1 Transmits Signal to the Nucleus
(precedingEvent)	[Reaction:R-XTR-1912357] ITCH ubiquitinates DTX
(inferredTo)	[Reaction:R-HSA-1980125] ITCH binds DTX