Reactome | STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space

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STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space Show undefined attributes

catalystActivity	[CatalystActivity:10664512] molecular carrier activity of STAR [mitochondrial intermembrane space]
category	transition
compartment	[Compartment:17906] mitochondrial outer membrane [Compartment:70101] cytosol [Compartment:17927] mitochondrial intermembrane space
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10664514
displayName	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space
eventOf	[Pathway:R-XTR-196108] Pregnenolone biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space - Homo sapiens
input	[Complex:R-XTR-196124] STARD3:STARD3NL, STARD4,6:CHOL [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space cholesterol(in) = cholesterol(out)
output	[SimpleEntity:R-ALL-193156] CHOL [mitochondrial inner membrane] [CandidateSet:R-XTR-196094] STARD3:STARD3NL, STARD4,6 [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-196126
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-196108] Pregnenolone biosynthesis
(precedingEvent)	[Reaction:R-XTR-193054] Oxidation of cholesterol to 22beta-hydroxycholesterol
(inferredTo)	[Reaction:R-HSA-196126] STAR mediates CHOL translocation from cytosol to mitochondrial intermembrane space

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