Reactome | CYP17A1 17-hydroxylates P4 to 17aHPROG

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CYP17A1 17-hydroxylates P4 to 17aHPROG Show undefined attributes

catalystActivity	[CatalystActivity:10664001] steroid 17-alpha-monooxygenase activity of CYP17A1 [endoplasmic reticulum membrane]
category	transition
compartment	[Compartment:70101] cytosol [Compartment:12045] endoplasmic reticulum membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10664007
displayName	CYP17A1 17-hydroxylates P4 to 17aHPROG
eventOf	[Pathway:R-XTR-193048] Androgen biosynthesis - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-193099] CYP17A1 cleaves 17aHPROG to ANDST - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG - Homo sapiens
input	[SimpleEntity:R-ALL-70106] H+ [cytosol] [SimpleEntity:R-ALL-29364] NADPH [cytosol] [SimpleEntity:R-ALL-29368] O2 [cytosol] [SimpleEntity:R-ALL-193055] P4 [cytosol]
isInDisease	false
isInferred	true
maxDepth	1
name	CYP17A1 17-hydroxylates P4 to 17aHPROG Hydroxylation of progesterone to form 17alpha-hydroxyprogesterone progesterone + NADPH + H+ + O2 => 17alpha-hydroxyprogesterone + NADP+ + H2O
output	[SimpleEntity:R-ALL-193092] 17aHPROG [cytosol] [SimpleEntity:R-ALL-29356] H2O [cytosol] [SimpleEntity:R-ALL-29366] NADP+ [cytosol]
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-193072
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-193048] Androgen biosynthesis
(precedingEvent)	[Reaction:R-XTR-193099] CYP17A1 cleaves 17aHPROG to ANDST
(inferredTo)	[Reaction:R-HSA-193072] CYP17A1 17-hydroxylates P4 to 17aHPROG

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