Reactome | Factor B binds to surface-associated C3b

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Factor B binds to surface-associated C3b Show undefined attributes

category	binding
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10662857
displayName	Factor B binds to surface-associated C3b
eventOf	[Pathway:R-XTR-173736] Alternative complement activation - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
followingEvent	[Reaction:R-XTR-183122] Factor D cleaves C3b-bound Factor B - Xenopus tropicalis
inferredFrom	[Reaction:R-HSA-183126] Factor B binds to surface-associated C3b - Homo sapiens
input	[Complex:R-XTR-981542] Cell surface:C3b [plasma membrane] [EntityWithAccessionedSequence:R-XTR-173738] cfb [extracellular region]
isInDisease	false
isInferred	true
maxDepth	1
name	Factor B binds to surface-associated C3b
output	[Complex:R-XTR-173737] Cell surface:C3b:CFB [plasma membrane]
precedingEvent	[Reaction:R-XTR-981539] C3b binds to cell surface - Xenopus tropicalis
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-183126
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-173736] Alternative complement activation
(precedingEvent)	[Reaction:R-XTR-183122] Factor D cleaves C3b-bound Factor B
(inferredTo)	[Reaction:R-HSA-183126] Factor B binds to surface-associated C3b

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