Reactome | PI is hydrolyzed to 1-acyl LPI by PLA2[15]

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PI is hydrolyzed to 1-acyl LPI by PLA2[15] Show undefined attributes

catalystActivity	[CatalystActivity:10683897] A2-type glycerophospholipase activity of PLA2(15) [extracellular region]
category	transition
compartment	[Compartment:984] extracellular region [Compartment:876] plasma membrane
created	[InstanceEdit:10651445] Weiser, Joel, 2026-03-16
dbId	10683901
displayName	PI is hydrolyzed to 1-acyl LPI by PLA2[15]
eventOf	[Pathway:R-XTR-1482922] Acyl chain remodelling of PI - Xenopus tropicalis
evidenceType	[EvidenceType:9984902] inferred by electronic annotation
inferredFrom	[Reaction:R-HSA-1602377] PI is hydrolyzed to 1-acyl LPI by PLA2[15] - Homo sapiens
input	[SimpleEntity:R-ALL-109276] H2O [extracellular region] [SimpleEntity:R-ALL-426658] PI [plasma membrane]
isInDisease	false
isInferred	true
maxDepth	1
name	PI is hydrolyzed to 1-acyl LPI by PLA2[15]
output	[SimpleEntity:R-ALL-1602420] 1-acyl LPI [plasma membrane] [SimpleEntity:R-ALL-1602366] LCFA(-) [plasma membrane]
precedingEvent	[Reaction:R-XTR-1675994] PI3P is dephosphorylated to PI by SYNJ/MTMs at the plasma membrane - Xenopus tropicalis [Reaction:R-XTR-1675988] PI4P is dephosphorylated to PI by SYNJ at the plasma membrane - Xenopus tropicalis
regulatedBy	[NegativeRegulation:10683894] Negative regulation by 'PLA2R1(21-?) [extracellular region]'
releaseDate	2026-03-25
schemaClass	Reaction
species	[Species:205621] Xenopus tropicalis
stId	R-XTR-1602377
summation	[Summation:9984901] This event has been computationally inferred from an event that has been demonstrated in another species. The inference is based on the homology mapping from PANTHER. Briefly, reactions for which all involved PhysicalEntities (in input, output and catalyst) have a mapped orthologue/paralogue (for complexes at least 75% of components must have a mapping) are inferred to the other species. High level events are also inferred for these events to allow for easier navigation. More details and caveats of the event inference in Reactome. For details on PANTHER see also: http://www.pantherdb.org/about.jsp

Referrals

(hasEvent)	[Pathway:R-XTR-1482922] Acyl chain remodelling of PI
(inferredTo)	[Reaction:R-HSA-1602377] PI is hydrolyzed to 1-acyl LPI by PLA2[15]